Self-organization of multi-cellular systems by mechanical forces from extracellular spaces
Elucidate how “forces derived from the extracellular environment” control the emergence of tissue function.
Mechanochemical feedback and emergence of tissue function in luminal tissues
We explore mechanochemical feedback in multiple luminal tissues during morphogenesis. We focus on the processes of the cells responding to the forces exerted by the lumen and transforming the luminal tissues. We will elucidate how the feedback mechanism between forces and molecules contributes to constructing organ morphology and its function.
Li-Kun PhngRIKEN Center for Biosystems Dynamics Research
Toshihiko FujimoriNational Institute for Basic Biology, National Institutes of Natural Sciences
Asako ShindoInstitute of Molecular Embryology and Genetics, Kumamoto University
Cooperation of mechanical forces during brain architecture formation
We will elucidate the mechanochemical coupling mechanism by which neurons and glia respond to external forces received from the environment while generating cell intrisic forces to produce the most effective movement and cell shape during the formation of the cellular architecture of the brain.