We explore mechanochemical feedback in multiple luminal tissues during morphogenesis. We focus on the processes of the cells responding to the forces exerted by the lumen and transforming the luminal tissues. We will elucidate how the feedback mechanism between forces and molecules contributes to constructing organ morphology and its function.

We will elucidate the mechanochemical coupling mechanism by which neurons and glia respond to external forces received from the environment while generating cell intrisic forces to produce the most effective movement and cell shape during the formation of the cellular architecture of the brain.