Member

Toshihiko Fujimori

  • Co-PI
National Institute for Basic Biology, National Institutes of Natural Sciences
Professor
Research Areas
Developmental Biology
Keywords
Mammalian development, Early Development, Feto-maternal interactions, Imaging

Related Outline

The aim of our research is to understand the events underlying early mammalian development. One of the characteristics of mammalian embryonic development is that embryogenesis proceeds in the oviducts and the uterus of the mother, and the interactions between the embryo and maternal tissue are essential in this process. Another characteristic is the highly regulative potential of embryos. Cells within embryos interact with their environment and establish their own fates and behaviors. We want to provide basic and fundamental information about the specification of the differentiation of cell lineages, embryonic axes, cell behaviors, body shape regulation, and tissue morphology in early mammalian development. We are also interested in the relationship between embryos and their environment, the oviducts and the uterus. And we have been analyzing the changes in the morphology and characteristics of these maternal organs supporting embryonic development.

Career

1995 PostDoc, Harvard Univ.
1997 Assistant Professor, Osaka Univ.
1998 Assistant Professor, Kyoto Univ.
2006 Visiting Scientist, Riken CDB
2008 Professor, National Institute for Basic Biology

Representative Achievements

  • Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multiciliated cells
    F.M. Usami, M. Arata, D. Shi, S. Oka, Y. Higuchi, F. Tissir, M. Takeichi, and T. Fujimori
    J Cell Sci
    DOI: https://doi.org/10.1242/jcs.257006
  • Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause
    C. Kamemizu and T. Fujimori
    Biol Reprod
    DOI: https://doi.org/10.1093/biolre/ioz017
  • ROSA26 reporter mouse lines and image analyses reveal the distinct region-specific cell behaviors in the visceral endoderm
    T. Abe, N. Kutsuna, H. Kiyonari, Y. Furuta and T. Fujimori
    Development
    DOI: https://doi.org/10.1242/dev.165852
  • Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes
    Y. Toyooka, S. Oka and T. Fujimori
    Dev Biol
    DOI: https://doi.org/10.1016/j.ydbio.2016.01.011
  • Mechanical Regulation of Three-Dimensional Epithelial Fold Pattern Formation in the Mouse Oviduct
    H. Koyama, D. Shi, M. Suzuki, N. Ueno, T. Uemura and T. Fujimori
    Biophys J
    DOI: https://doi.org/10.1016/j.bpj.2016.06.032
  • Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct
    D. Shi, K. Komatsu, M. Hirao, Y. Toyooka, H. Koyama, F. Tissir, A.M. Goffinet, T. Uemura, and T. Fujimori
    Development
    DOI: https://doi.org/10.1242/dev.115659
  • Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter
    T. Abe , A. Sakaue-Sawano, H. Kiyonari, G. Shioi, K. Inoue, T. Horiuchi, K. Nakao, A. Miyawaki, S. Aizawa and T. Fujimori
    Development
    DOI: https://doi.org/10.1242/dev.084111
  • Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging
    T. Abe, H. Kiyonari, G. Shioi, K. Inoue, K. Nakao, S. Aizawa and T. Fujimori
    Genesis
    DOI: https://doi.org/10.1002/dvg.20753
  • Blastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape
    Y. Kurotaki, K. Hatta, K. Nakao, Y. Nabeshima, and T. Fujimori,
    Science
    DOI: https://doi.org/10.1126/science.1138591