Member

Satoru Okuda

  • Co-PI
Nano Life Science Institute, Kanazawa University
Associate Professor
Research Areas
Biomechanics, Biophysics, Computational Mechanics, Rheology, Developmental Biology
Keywords
Self-organization, Stem Cell Organoid, Multiscale Simulation, 3D Vertex Model, AFM Measurement

Related Outline

Satoru is a mechanical engineer with an interest in the self-organizing structure formation of living systems, especially the mechanics in 3D multicellular dynamics. His lab has established computational frameworks to simulate 3D multicellular dynamics at single-cell resolution and integrated them with pluripotent stem cell-derived organoid culture, micromechanical testing, and mechanics-based theoretical analysis. With this combined technology, his lab aims to achieve comprehensive, quantitative prediction and highly accurate manipulation of multicellular dynamics.

Career

Satoru completed his B.S. (Engineering Science) in 2008 at the Kyoto University, M.S. (Mechanical Engineering) in 2010 (Prof. Masaki Hojo’s lab), and Ph.D. (Engineering) in 2013 (Prof. Taiji Adachi lab). JSPS Research Fellow (DC1). He has been a research scientist at RIKEN CDB (Director Yoshiki Sasai lab and Team Leader Mototsugu Eiraku lab). Since 2016, he has been a RIKEN Special Postdoctoral Researcher and a JST-PRESTO researcher. In 2019, he was appointed as Associate Professor at Nano Life Science Institute, Kanazawa University.
Hobbies: Running and Singing

Representative Achievements

  • Continuum modeling of non-conservative fluid membrane for simulating long-term cell dynamics
    Satoru Okuda, Katsuhiko Sato, Tetsuya Hiraiwa
    The European Physical Journal E
    DOI: https://doi.org/10.1140/epje/s10189-022-00223-0
  • Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
    Kentaro Kajiwara, Ping-Kuan Chen, Yuichi Abe, Satoru Okuda, Shunsuke Kon, Jun Adachi, Takeshi Tomonaga, Yasuyuki Fujita, Masato Okada
    Current Biology
    DOI: https://doi.org/10.1016/j.cub.2022.06.038
  • Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue
    Satoru Okuda, Katsuhiko Sato
    Biophysical Journal
    DOI: https://doi.org/10.1016/j.bpj.2022.04.018
  • A Mechanical Instability in Planar Epithelial Monolayers Leads to Cell Extrusion
    Satoru Okuda, Koichi Fujimoto
    Biophysical Journal
    DOI: https://doi.org/10.1016/j.bpj.2020.03.028
  • Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
    Igor Kondrychyn, Douglas J. Kelly, Núria Taberner Carretero, Akane Nomori, Kagayaki Kato, Jeronica Chong, Hiroyuki Nakajima, Satoru Okuda, Naoki Mochizuki, Li-Kun Phng
    Nature Communications
    DOI: https://doi.org/10.1038/s41467-020-19308-5
  • Apical junctional fluctuations lead to cell flow while maintaining epithelial integrity
    Satoru Okuda, Erina Kuranaga, Katsuhiko Sato
    Biophysical Journal
    DOI: https://doi.org/10.1016/j.bpj.2019.01.039
  • Strain-triggered mechanical feedback in self-organizing optic cup morphogenesis
    Satoru Okuda, Nozomu Takata, Yuiko Hasegawa, Masako Kawada, Yasuhiro Inoue, Taiji Adachi, Yoshiki Sasai, Mototsugu Eiraku
    Science Advances
    DOI: https://doi.org/10.1126/sciadv.aau1354
  • Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching
    Satoru Okuda, Takashi Miura, Yasuhiro Inoue, Taiji, Adachi, Mototsugu Eiraku
    Scientific Reports
    DOI: https://doi.org/10.1038/s41598-018-20678-6
  • Induced cortical tension restores functional cell junctions to adhesion-defective carcinoma cells
    Shoko Ito, Satoru Okuda, Masako Abe, Mari Fujimoto, Tetsuo Onuki, Tamako Nishimura, Masatoshi Takeichi
    Nature Communications
    DOI: https://doi.org/10.1038/s41467-017-01945-y