Related Outline
We are investigating the dynamics and regulatory mechanisms of intercellular junctions in epithelial cells. These junctions are not merely physical attachments but play crucial roles in mechanical and biochemical signal transduction at both the cellular and tissue levels. Our goal is to elucidate how such adhesive structures are formed and dynamically remodeled to facilitate tissue morphogenesis during processes such as development and regeneration.
Career
2025 – Present Assistant Professor, Graduate School of Biostudies, Kyoto University
2024 – 2025 Program-Specific Researcher (JSPS-PD), Graduate School of Biostudies, Kyoto University
2023 – 2024 JSPS Postdoctoral Fellow, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences
2022 – 2023 Project Research Stuff, National Institute for Basic Biology, National Institutes of Natural Sciences
2022 Ph.D. at Graduate School of Arts and Sciences, The University of Tokyo
Representative Achievements
- ZO-1 shuttles between tight junctions and podosomes by riding ERK activation waves during collective cell migration
Sayuki Hirano; Yohei Kondo; Noriyuki Kinoshita; Tetsuhisa Otani; Mikio Furuse; Naoto Ueno; Kazuhiro Aoki
bioRxiv
DOI: 10.1101/2024.08.09.607278 - Alignment of the cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish planar cell polarity
Sayuki Hirano; Yusuke Mii; Guillaume Charras; Tatsuo Michiue
Development
DOI: 10.1242/dev.200515 - FRET-based tension measurement across actin-associated mechanotransductive structures using Lima1
Sayuki Hirano; Takayoshi Yamamoto; Tatsuo Michiue
The International Journal of Developmental Biology
DOI: 10.1387/ijdb.180110tm - Fam46a regulates BMP-dependent pre-placodal ectoderm differentiation in Xenopus
Tomoko Watanabe; Takayoshi Yamamoto; Kohei Tsukano; Sayuki Hirano; Ayumi Horikawa; Tatsuo Michiue
Development
DOI: 10.1242/dev.166710